Three new steroidal saponins from Aspidistra letreae plants and their cytotoxic activities

Duc Viet Ho, Hanh Nhu Thi Hoang, Hung Quoc Vo, Khan Viet Nguyen, Ty Viet Pham, Anh Tuan Le, Kiem Van Phan, Hien Minh Nguyen, Hiroyuki Morita & Hoai Thi Nguyen 

Journal of Natural Medicines volume 74, pages591–598(2020) Cite this article

DOI: https://doi.org/10.1007/s11418-020-01395-9

Abstract

Three new steroidal saponins, aspiletreins A–C (1–3), together with 2H-chromen-2-one (4), and α-tocopherol (5), were isolated from whole Aspidistra letreae plants collected in Vietnam. Their structures were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR, IR, and HRESIMS, and by comparison with the reported data in the literature. Compounds 1–3 exhibited moderate cytotoxicities against the LU-1, HeLa, MDA-MB-231, HepG2, and MKN-7 human cancer cell lines, with IC₅₀ values ranging from 7.69 ± 0.40 to 20.46 ± 3.11 µM.